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Showing posts with label heart. Show all posts
Showing posts with label heart. Show all posts

Wednesday, March 27, 2013

Lionheart's heart smelled sweet for heaven, scientists find

VERSAILLES, France (Reuters) - The heart of the Lionheart was embalmed with daisy, myrtle, mint and frankincense, kept sweet-smelling in saintly fashion in hope of speeding King Richard of England's ascent to heaven.

French scientists have analyzed the organ, kept at Rouen Cathedral since the death of Richard I, known as The Lionheart; they found it was wrapped in linen, treated with mercury, herbs and reverence, and that it held pollen confirming records of his death from a war wound in the spring of 1199, in central France.

What Philippe Charlier, who published his paper on Thursday, did not find in the dirty powder that is all that is left of the heart was any trace of toxin - blunting tales that the Crusader king was hit by a poisoned crossbow bolt. Medieval dirt and an infected wound most likely caused his lingering death, aged 41.

For the English, fresh from rediscovering the remains of the Lionheart's 15th-century descendant, namesake and Shakespearian villain Richard III under a municipal car park, the findings of Charlier's team may revive memories of a monarch who lives on in popular culture as the absent but "good King Richard" in the tales of Robin Hood.

For the French, whom Richard was fighting when he died, his reputation as a ruthless warrior, against Muslims in the Holy Land but also in Europe, may explain the care taken to preserve the king's heart in a costly manner bound up in the medieval mind with the embalming of Jesus after the crucifixion.

"He had been rather criticized during the Crusade when he had been particularly cruel," Charlier, a youthful television celebrity in France, told a news conference at Versailles.

"People started to talk when he died, so very special care had to be given to his body and especially to his heart, with herbs and spices which were not chosen by accident.

"We know from historical sources that those herbs and spices were used to make the time Richard the Lionheart would spend in purgatory shorter and give him a kind of odor of sanctity.

"So this study is almost a scientific study of an artificial odor of sanctity, a man-made one," added Charlier, dubbed the "Indiana Jones of the graveyards" by French media for his high-profile analyses of relics and royal remains in recent years.

NO DOUBT

Unlike some such discoveries, notably genetic testing of the bones found to belong to Richard III or Charlier's analysis of a head which he concluded was that of Henri IV, France's great Renaissance king, no research was conducted at Rouen to determine whether the heart was indeed that of Richard I.

The organ was first rediscovered during work at the cathedral in the 19th century, in a lead casket dated to the 12th or 13th centuries bearing the inscription in Latin: "hic iacet cor ricardi regis anglorum" - Here lies the heart of Richard, king of the English. Its provenance was not in doubt, Charlier said, noting a prevalent practice at the time of dividing up royal remains for burial in different sites.

Among his previous work, Charlier, 35, has found that relics of Joan of Arc actually came from an Egyptian mummy and verified dried blood on a handkerchief was from the guillotined Louis XVI by DNA testing to link it to other royal remains.

In their paper in "Scientific Reports", Charlier of University Hospital Raymond Poincare and his team wrote that they found traces of linen, myrtle, daisy, mint, frankincense, creosote, mercury and possibly lime.

They had no clearly identifiable human tissue but said the embalmers themselves were not necessarily to blame - the rot may have been due to decay in the lead box and to damp getting in.

Whether they were successful in accelerating the process by which Richard entered paradise is a matter of pure speculation.

Charlier, whose Twitter account describes his "patients" as "you (soon), ... Henri IV, Richard the Lionheart, Louis XVI etc", noted in the paper that a 13th-century bishop had ruled: "Richard the Lionheart spent 33 years in Purgatory as expiation for his sins, and ascended to Heaven only in March 1232."

(Additional reporting by Vicky Buffery in Paris and Reuters Television in Versailles; Writing by Alastair Macdonald; Editing by Andrew Heavens)


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Monday, August 13, 2012

Former astronaut Armstrong has heart surgery

COLUMBUS, Ohio (AP) — Neil Armstrong, the first man to walk on the moon, was recovering from heart surgery, days after his 82nd birthday.

A NASA spokesman talked to Armstrong's wife, Carol, on Wednesday and said only that he was recovering. Armstrong's birthday was Sunday.

It wasn't clear where the surgery occurred or where the former astronaut was recuperating.

NASA Administrator Charles Bolden wished Armstrong a quick recovery from cardiac bypass surgery in a Facebook statement.

"Neil's pioneering spirit will surely serve him well in this challenging time and the entire NASA Family is holding the Armstrong family in our thoughts and prayers," the statement said.

Armstrong commanded the Apollo 11 spacecraft that landed on the moon on July 20, 1969, and he radioed back to Earth the historic news of "one giant leap for mankind." He spent nearly three hours walking on the moon with fellow astronaut Edwin "Buzz" Aldrin.

A message Wednesday on Aldrin's Twitter account also wished Armstrong well.

Armstrong and his wife married in 1999 and made their home in the Cincinnati suburb of Indian Hill, but he has largely stayed out of public view in recent years.

He spoke at Ohio State University during a February event honoring fellow astronaut John Glenn and the 50th anniversary of Glenn becoming the first American to orbit the Earth. In May, Armstrong joined Gene Cernan, the last man to walk on the moon, at Pensacola Naval Air Station in Florida to support the opening of The National Flight Academy, which aims to teach math and science to kids through an aviation-oriented camp.


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Wednesday, June 15, 2011

Scientists show heart can repair itself, with help

By Kate Kelland

LONDON | Wed Jun 8, 2011 1:02pm EDT

LONDON (Reuters) - British scientists have managed to transform a type of stem-like cell in adult mouse hearts into functioning heart muscle in research proving that the heart has dormant repair cells that can be reactivated.

Although the research has yet to be translated into humans and is in its very early stages, the results suggest that in the future, a drug could be developed to prompt and prime hearts damaged by cardiac arrest into repairing themselves.

"I could envisage a patient known to be at risk of a heart attack taking an oral tablet...which would prime their heart so that if they had a heart attack the damage could be repaired," said Paul Riley of University College London, who led the study.

Major advances in medical science in recent years have helped cut the number of people who die from heart attacks, but the damage an attack causes -- when heart cells die as they become starved of oxygen -- is currently permanent.

If enough dead tissue forms, patients can develop heart failure, a debilitating condition in which the heart is not able to pump enough blood around the body.

Scientists around the world are investigating various ways to regenerate heart tissue, but for now people with severe heart failure must use mechanical devices or hope for a transplant.

Riley's team, whose study was published in the journal Nature Wednesday, targeted particular cells found in the outer layer of the heart, called the epicardium.

PROGENITOR CELLS

These cells, referred to as epicardium-derived progenitor cells (EPDCs), are known to be able to transform into a number of specialist cells, including heart muscle, in developing embryos.

Scientists had previously thought EPDCs' ability to transform was lost in adulthood, but in this study Riley's team found that by treating the healthy hearts of adult mice with a molecule called thymosin beta 4, they were able to "prime" the heart to repair itself after damage.

After causing heart attacks in the primed mice, the researchers also gave them a booster dose of thymosin beta 4 and this prompted the EPDCs to transform into cardiomycytes, and integrate with existing muscle.

"These cardiomycytes can link into the existing muscle of the heart and they home to the area of injury," Riley told reporters at a briefing in London. "And they are also both structurally and functionally coupled to the heart, and therefore represent a bona fide source of new heart muscle."

He said that in this study the priming and boosting technique was able to improve the function of the damaged mouse hearts by up to 25 percent -- an improvement which would make a dramatic difference to patients with heart failure if it could be translated into humans.

In previous studies, thymosin beta 4 has been shown to encourage regrowth of blood vessels and improve heart function after injury in mice, but this is the first time researchers have used it to regenerate functioning heart muscle.

Riley said his team was looking closely at this chemical and would be screening thousands of other potential drug candidates to see if they might have a similar effect on EPDCs.

(Editing by Mark Heinrich)


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